Coordinator:
Dr. Daniel Figeys
Office: Rm 4510 RGN
Tel: 562-5800 xt8674
Email: dfigeys@uottawa.ca
Time and Location
451 Smyth Rd
Roger Guindon Hall
Rm 4161
Tuesdays 1-4pm
First class: Jan 5 2010
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Presentation papers:
We will have two types of presentation
during this course.
The first type of presentation
will be a 30 minute presentation on one of the following papers. Please
note that students will present on Feb 9th and 16th. Each paper will
have a presenter (30 minutes) and a respondent (in charge of driving a
10 minute discussion). You will be marked as a presenter and as a
respondent. Papers will be assigned by random draw
on January 5th. If you would like to select your papers (one as
presenter and one as respondent) prior to the first day of class, email
Dr. Figeys with your preference and this page will be updated
accordingly.
Session 1: February 9th
and 16th.
Identification
of b-Secretase (BACE1) Substrates Using
Quantitative Proteomics, Matthew L. Hemming1, Joshua E. Elias2¤,
Steven P. Gygi2, Dennis J. Selkoe1* Presenter:
Kessiri Kongmanas Responder:
Trevor Greenham
In
depth qualitative and quantitative profiling of tyrosine
phosphorylation using a combination of phosphopeptide immuno-affinity
purification and stable isotope dimethyl labeling, Paul J.
Boersema1,2,*, Leong Yan Foong3,*, Vanessa M.Y. Ding3,*, Simone
Lemeer1,2,*,†,Bas van Breukelen1,2, Robin Philp3, Jos
Boekhorst4, Berend Snel4, Jeroen den Hertog5,6, Andre B. H. Choo3,7#
and Albert J. R. Heck1,2,8#
Full Dynamic Range Proteome Analysis of S. cerevisiae
by Targeted Proteomics Paola Picotti,1 Bernd Bodenmiller,1 Lukas N.
Mueller,1 Bruno Domon,1 and Ruedi Aebersold1,2,3,4,* Presenter:Fatima Hafizi
Responder:
Brett Hawley
(Picotti et al. supplement info)
Components of Ubiquitin-Protein Ligase System,
RESOLUTION, AFFINITY PURIFICATION, AND ROLE IN PROTEIN BREAKDOWN*,
Avram HershkoS, Hannah Heller, Sarah Elias, and Aaron Ciechanover
Presenter:George Styles Responder: Jon
Labriola
Identification of a
Novel Force-Generating Protein, Kinesin, Involved in Microtubule-Based
Motility, Ronald D. Vale,*tt Thomas S. Reese,* and
Michael P. Sheetz,*
Variable Control of Ets-1 DNA Binding by Multiple
Phosphates in an Unstructured Region Miles A. Pufall, Gregory M. Lee,
Mary L.
Nelson, Hyun-Seo Kang, Algirdas Velyvis, Lewis E. Kay, Lawrence P.
McIntosh,
Barbara J. Graves Presenter:
Saud AyedResponder:
Adam Buffone
A solution
NMR study showing that active site ligands and
nucleotides directly perturb the allosteric equilibrium in aspartate
transcarbamoylase Algirdas Velyvis, Ying R. Yang, Howard K. Schachman,
Lewis E.
Kay Presenter:
Ian HurdaResponder:
Fatima Hafizi
Enzymatic and
structural insights for substrate specificity of a family of jumonji
histone lysine demethylases John R Horton1,4, Anup K Upadhyay1,4, Hank
H Qi2,3,4, Xing Zhang1, Yang Shi2,3 & Xiaodong Cheng1 Presenter:Jon
LabriolaResponder:
George Styles
Fungal Rtt109
histone acetyltransferase is an unexpected structural homolog of
metazoan p300/CBP Yong Tang1, Marc A Holbert2, Hugo Wurtele3, Katrina
Meeth1, Walter Rocha3, Marlene Gharib3, Eva Jiang1, Pierre Thibault3,
Alain Verreault3, Philip A Cole2 & Ronen Marmorstein1,4 Presenter:
Brett Hawley Responder: Saud Ayed
Identification of protein O-GlcNAcylation sites using
electron transfer dissociation mass spectrometry on native peptides
Robert J. Chalkleya, Agnes Thalhammerb, Ralf Schoepfera,b, and A. L.
Burlingamea,1
Presenter:
Trevor Greenham Responder: Ian Hurda
(Chalkleya supp info)
Modulation of protein stability by O-glycosylation in
a designed Gc-MAF analog Justin Spiriti 1, Federica Bogani 1, Arjan van
der Vaart ⁎, Giovanna Ghirlanda ⁎ Presenter:
Adam Buffone
Responder:
Kessiri Kongmanas
Conformational stabilities of guinea pig OCP1 and OCP2
Anmin Tan, Michael T. Henzl ⁎
The second type of presentation will occur on
April 13th. It is increasingly common in some conferences and in board
meetings to only have 5-10 minutes to explain an idea or to present
research. Hence, the second type of presentation will help you get
ready to deliver short presentations while still carying the message.
you will each have to select a paper from the litterature relevant to
the course. This needs to be a peer reviewed article with new data and
cannot be a review nor an opinion article. As well, you can not choose
a paper related to your past or current research. On April 13th, you
will each have 10 minutes to explain your paper to the group. You need
to provide me with a copy of the paper you selected by March 2nd at the
lattest.
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UNIVERSITY OF
OTTAWA