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Prabhat Arya

B.Sc. (Hons), Delhi University, India, 1978
M.Sc., Delhi University, India, 1980
M.Phil., Delhi University, India, 1981
Ph.D. (Synthetic Organic Chemistry), Delhi University, India, 1985

Senior Research Officer, Steacie Institute for Molecular Sciences, National Research Council of Canada
Adjunct Professor: Biochemistry, McGill University
Member, International Advisory Board, QSAR & Combinatorial Science (Wiley-VCH)
Member, Steering Committee, CIHR Network for Chemical Biology

Research Interests

Dissecting dynamic protein-protein interactions in a systematic manner by small-molecules is a post-genomics research dream and it presents tremendous challenges and opportunities in developing new therapeutic directions in bio-medical research. Combining the skills of modern organic synthesis with the library generation technologies on solid phase and the small molecule microarray printing technology, the Arya laboratory is developing high-throughput approaches to explore the natural product-like chemical space. Working in collaboration with the cell/chemical biology community, these compounds are then utilized in search for chemical dissectors of biomacromolecular (i.e. protein-protein) interactions and dynamic multiple protein networking-based signaling pathways.

Selected Publications

Prabhat Arya, Reni Joseph, Zhonghong Gan and Bojana Rakic. Exploring New Chemical Space by Stereocontrolled Diversity Oriented Synthesis. Chemistry & Biology, 12 , 163-180 (2005).

Ayub Reayi and Prabhat Arya. Natural Product-like Chemical Space: Search for Chemical Dissectors of Macromolecular Interactions. Curr. Opin. Chem. Biol. 9 , 240-247 (2005)

Prabhat Arya and Hans Joerg Roth. Combinatorial Chemistry- Editorial Overview. Curr. Opin. Chem. Biol., 9 , 229-231 (2005)

Zhonghong Gan, P. Thirupathi Reddy, Sophie Quevillon, Samuel Couve-Bonnaire and Prabhat Arya. Stereocontrolled, Solid Phase Synthesis of a 90 Membered Library of Indoline Alkaloid-like Polycycles from an Enantioenriched Aminoindoline Scaffold . Angew. Chem. Int. Ed. 44 , 1366-1368 (2005).

Recent Presentations

• Gordon Conference-Combinatorial Chemistry, Oxford, UK (2004)
• Work Shop on, “Organic Synthesis Directed Towards Chemical Biology and Chemical Genetics” at the National Chemical Laboratory, Pune, India (4 Lectures) (2004)
• Lecture 1: Organic Synthesis in Post Genomics Age- Challenges and Opportunities (2004)
• Lecture 2: Combinatorial Approaches to Carbohydrates- Small Molecule Probes for Glycobiology (2004)
• Lecture 3: Combinatorial Chemistry in Chemical Genomics Age (2004)
• Lecture 4: Stereocontrolled Diversity Oriented Synthesis- Natural Product-like Complex Polycyclics as Chemical Probes (2004)
• IUPAC Meeting-Biodiversity and Natural Products, New Delhi, India (2004)
• Chemical Biology Workshop, Dept of Biochemistry, McGill University (2004)
• IBC's Inaugural Annual International Conference on High Throughput Chemistry in Drug Discovery, San Diego (March, 2005) (presented by Dr. Reni Joseph, a former group member)
• CSC Meeting, Saskatoon- Symposium on Drug Design Targeting Protein-Protein Interactions, May 28-June 1 (2005)
• Diversity Oriented Synthesis Meeting, Boston, Sept 22-23 (2005)
• Chemical Biology Meeting, Lyon, France, December 4-5 (2005)