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Ruedi Aebersold

Dr. Aebersold completed his undergraduate studies in biology at the University of Basel, Switzerland in 1979 and received a Ph.D. in cell biology at the Biocenter of the University of Basel in 1984. Holding fellowships from the Swiss National Science Foundation and EMBO, he joined the California Institute of Technology as a postdoctoral fellow (1984-86) and remained at Caltech as a senior research fellow (1986-88). In 1988, he joined the University of British Columbia in Vancouver as an assistant professor in the Department of Biochemistry and Molecular Biology and as a senior investigator at the Biomedical Research Centre. In 1993, he moved to the University of Washington as an Associate Professor in Molecular Biotechnology and was promoted to full Professor in 1998. He served as the Associate Director for the Science and Technology Center for Molecular Biotechnology from 1994-2000. In 2000, he left the University of Washington and joined the Institute for Systems Biology as co-founder and full faculty member. In November 2004, he assumed an appointment as Professor of Systems Biology, Institute of Biotechnology, ETH-Zurich and Faculty of Natural Sciences, University of Zurich.

Dr. Aebersold's research focuses on developing new methods and technologies for quantitative proteomics and for applying this emerging technology to enhance our understanding of the structure, function, and control of complex biological systems. Current applications of quantitative proteomics technology are directed towards the discovery of proteins markers that differentiate cancer cells from their normal counterparts, to the investigation of the mechanisms of fundamental cellular processes by the comparative analysis of the gene and protein expression profiles in cells at different states, and to studies in the area of medical microbiology.

Dr. Aebersold is an advisory editor for the journal Physiological Genomics, has been a member of the Editorial Advisory Boards of Protein Science (1992-‘98 ), Molecular and Cellular Proteomics (2001-present) , Functional Proteomics (1999- present) , Analytical Biochemistry (1991-2000 ) Functional and Integrative Genomics (1999-present), Electrophoresis (1989-1993 ), and Genome Technology (2003- ) . He is the 2002 recipient of the Widmer Award, the ASMS Biemann Medal, and the World Technology Network Award in the biotechnology category.

Ruedi Aebersold

Institute for Biotechnology, ETH Zurich, Switzerland and Institute for Systems Biology, Seattle, USA

An important goal of Systems Biology is the analysis of dynamic networks of interacting biomolecules. It is based on the insight that such networks have intrinsic properties determining their structure and function that are not apparent from the analysis of the isolated components that constitute the system and that are critical for an understanding of the function and control of the system as a whole. Systems biology was made possible by the availability of the complete genome sequence of the human and other species and by advances in biology, engineering and computer science that have collectively catalyzed  the emergence of technologies for the systematic and quantitative measurement of genomic and proteomic profiles and the integrative analysis of the obtained results.


Most biological networks involve proteins. Proteomics, the systematic analysis of proteins is therefore an important component of systems biology.  In this presentation we will discuss advances in quantitative proteomics as a genomic science and its application to the analysis of biological networks, specifically the analysis of the dynamic changes in protein interaction networks induced by changes in cellular state.