Keynote Speaker: Pamela Silver Department of Systems Biology, Harvard Medical School Discovery and Design of Biological Networks Biology presents us with an array of design principles. On the one hand, we have discovered novel connections within the nucleus that may optimize communication both within and from outside the nucleus. Conversely, we can also start to think about biological processes in a logical manner to both understand cells by rebuilding them but also as a way to re-think cell-based bioengineering. We are interested in combining transcription-based logic with post-transcriptional events such as protein localization and degradation to build cells that can, for example, count mitotic divisions and ultimately act as a measure of cell life span.